First off, you have to invert the vial down before you twist off the cap because the eye drops take way too long to drop down into your eyes if you do not do so. Not a big deal at all but another thing I notice is that I always wake up with eye crust the next morning after using these eye drops. This can be quite bothersome but if you've tried other brands and find that they are not helping your situation you can always give Optive Sensitive a try.
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